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The third stage is marked by the appearance in clinical practice highly active synthetic progestins and combined estrogen-progestinami (contraceptive) drugs. At this stage, the big distribution have received hormone therapy of AGE. Thus believed that the operation fades into the background, being relevant primarily when the failure of Intagra 100 mg online price and hormonal treatment.

The main morphological feature that distinguishes this category of Intagra 100 mg online price and changes from simple hyperplasia are atypical changes in both the structure of the epithelium lining the glands (structural atypia), and the structure of the cell nucleus (cellular atypia).

As a result of these modifications dienoguest acquired positive properties in terms of absorption, distribution in the body and metabolism that are close to the characteristics of Intagra 100 mg online price and derivative norprogesterone. This drug, with a very pronounced progestinum effect on the endometrium, other effects on the target tissue (estrogenic, anti-estrogenic and androgenic) was absent. Against this background, antigonadotropnym activity dienogest (suppression of secretion of FSH and LH) was determined not pronounced. So, antigonadotropnym activity dienogest (the ability to suppress the secretion of FSH and LH) in studies in women with preserved menstrual cycle was determined as weak. However, appointment to these patients dienogest (Visanne) orally, at a dose of 1 mg per day in the first phase of the cycle, significantly violated the mechanism of ovulation by eliminating predovlatorna increase secretion of estradiol associated with lack of ovulatory release of LH and FSH (violation of a positive feedback mechanism).

To this end: – patient with 5-day menstrualnopodobnoe reaction, which may occur 8-10 days after the last progestin введе162 tion, transferred to a cyclic treatment of combined (estrogen-progestinami) contraceptive drugs prescribed for contraceptive scheme for 4-6 cycles. Preference is given to preparations of order Intagra Intas Pharmaceuticals Ltd. 100 mg online and the second generation with a large progestin-only activity (Microgynon, Rigevidon) in patients older than 46 years (46-55 years) of steroid contraceptive drugs are prescribed continuously (1 tab. a day) for 3-4 months, which leads to the preservation of persistent amenorrhea.

Nonselective β-blockers adversely affect lipid and carbohydrate metabolism. In contrast, in recent years a highly selective β-blockers, virtually devoid of adverse side effects on the metabolism of buy Intagra® over the counter and carbohydrates and fats. These drugs currently are яв78 nebivolol, bisoprolol, metoprolol succinate in the form of delayed action and a number of other β-blockers in this class. As pointed out by the experts of the Russian scientific society of cardiology (2009), highly selective bisoprolol did not negatively affect carbohydrate metabolism: not marked prolongation of the hypoglycemic condition or increase the level of glucose and glycated hemoglobin in the blood plasma and the appearance of glycosuria. Cholesterol and triglycerides did not change significantly during treatment with this drug. The hypotensive effect of bisoprolol was equally pronounced among young and elderly patients.

Progestins, which are derivatives of buy Intagra 100 mg online and nortestosterone 120 Due to such modified molecules of norethisterone, was synthesized four highly active progestin: norethindrone acetate, was norethynodrel, ethynodiol acetate and lynestrenol. It was the first connection progestinum retains activity when taken orally, which is many times higher than the activity of progesterone administered parenterally. These four progestin belong to the first generation of medications designed for oral administration. The obtaining of these compounds have opened a new page in reproductive biology and made possible the development and widespread introduction into medical practice of hormonal contraceptives.

It was during this period adopted a "decision" about the entry of buy Intagra Intas Pharmaceuticals Ltd. without prescription and cells into the next mitotic cycle or the termination of fission Mitogenic factor, in the extracellular environment (primary messenger), launches a chain reaction, penetrating through the membrane into the cell. The number of chemical compounds, 48 may start the process of cell division (mitosis), is sufficiently large. However, the existence of a mechanism of specific binding of only the "right" mitogenic factor, saves the day, making the cell insensitive to inadequate and can be harmful influences. Otherwise, the cell would be helpless before an avalanche of similar impacts and would have died.

The first work related to the implementation of the idea of buy Intagra over the counter and hormonal contraception, was made G. Pincus (1956) more than 50 years ago. The author experimentally and clinically proved the effectiveness of using a modified progestin for the purpose of contraception.

M. F. Glazunov, 1971 In General, the concept of order Intagra Intas Pharmaceuticals Ltd. 100 mg online and "endometrial" in relation to the organs of the female reproductive system means the complex of morphological changes in target tissues characterized by excessive but controlled cell proliferation nonneoplastic nature in the form of hyperplasia, metaplasia and regeneration, without the development of cellular atypia and preservation of normal histological structure of tissues.

Very significant clinical value has ability of progestins to provide a systemic antiandrogenic effect, neutralizing the manifestations of Intagra® 100 mg price online and androgen associated with a number of hyperplastic processes in the female reproductive system (or tecomates polycystic ovarian hirsute symptoms without obvious signs of organic lesions of the ovaries or adrenal glands).

Treatment of patients with AGE at any age should begin with the appointment of buy Intagra Intas Pharmaceuticals Ltd. without prescription and progestins with confidence in the absence of endometrial adenocarcinoma (confirmed hysterography or hysteroscopy) associated with uterine fibroids or ovarian tumors. In the case of successful treatment in young women, this approach allows you to retain the menstrual function and the possibility of motherhood. In patients older hormone treatment avoids the risk of surgery, which could be significant, given the large amount of surgery and comorbidities.

However, the modification of Intagra® 100 mg price online and its molecules in the form of adding a double bond in position C6-7, methyl groups at C-6 and acetyl radical at C-17 leads to production of a progestin active ingestion — of nomegestrol acetate. Although Nesterov very similar in structure to nomegestrol acetate, however, the absence in its molecule a double bond in position C6-7 and the methyl group at C6 leads to the loss of this compound with oral activity.

It is known that the ovaries are in the process of order Intagra Intas Pharmaceuticals Ltd. 100 mg online and embryogenesis are formed of three completely different in histogenetic terms of tissues.

The first level of order Intagra® Intas Pharmaceuticals Ltd. 100 mg online and the cascade, referred to as "intercellular signal substance" or "primary messengers" or the more understandable term "extraclean signals", presented in the following way.

Trimegestone is one of the most active derivatives of Intagra® 100 mg online price and promegestone, quite active progestin, devoid of any androgenic properties. This compound is typically included in схе135 we the treatment of climacteric disorders in patients in postmenopausal women. Trimegestone in a minimum dose of 0.1 mg/day can cause secretory transformation of the endometrium in postmenopausal women who previously received a short training by estrogens.

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