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Initially, such reactions being studied progestin binding to the receptor protein used as the standard progesterone, tritium. Later progesterone was replaced by tritium promegestone (R 5020), is a synthetic progestin with progestin-only very high activity. The magnitude of progestin-only activity of best place to buy Super P Force 100mg + 60 mg online and the test compound is determined by its concentration, is able to inhibit competitive binding of 50% of the standard receptor protein (IC-50). This method accurately reflects progestinum activity of the resulting compounds, and modern scholars do not want to spend a lot of time waiting for the results of long-term testing of the drug on animals.

However, all was not so clear. Research in recent years in patients with SCA revealed signs of Super P Force 100mg + 60 mg online store and dysfunction of the hypothalamus, due to the peculiarities of the subtle regulation of its tropic effects on anterior pituitary.

However, in tests in vivo (test Trip maintenance of Super P Force 100mg + 60 mg for sale OTC and pregnancy, and inhibition of best place to buy Super P Force 100mg + 60 mg online and ovulation) the activity of the NES is much higher than levonorgestrel. The drug has no androgenic activity and does not bind hormone-binding globulin blood. The latter explains its short half-life and high clearance compared to other progestins. These properties of the progestin due to its preferential use for the purposes of contraception in the form of subcutaneous implants, which persist for two years and allocate about 80– 100 micrograms of hormone per day, providing highly effective contraception. The ovulation was absent, if the level of NES in the serum was determined not lower than 40 pkg/ml. Cervical mucus looked sparse and thinning, which drastically reduces its permeability to sperm in the test with penetration. Against this background, the patients were observed irregular bleeding, is typical when taking contraceptives containing only progestins.

The conventional notion is that the biological action of Super P Force online order Sunrise Remedies Pvt. Ltd. and steroid hormones is through their interaction with protein receptors, forming steroid molecule with the activated complex within the cell carrying the impulse action on a nuclear acceptor. In the spatial images of molecules of steroids have often the form "chair" and are curved so that cyclohexane rings (A, b and C, D) lie in different planes. The conformation change, the introduction of substituents (e.g., methyl or tinylogo radicals, usually in position 10 or 17 carbon atom of the steroid skeleton), or double bonds in the steroid skeleton of a molecule greatly affects its biological activity.

In the subsequent observation period of generic Super P Force in online store without prescription and 3 years the patient received estrogen-progestin combination in a cyclic mode to maintain the correct rhythm of the menstrual cycle (Klimen), ма106 lie dose of dexamethasone (0.5–1 mg/day, courses for 3 months, under the supervision of the daily excretion of 17-ketosteroids), low-calorie diet in combination with biguanidami and thyroid drugs, that has allowed to achieve reduction of body weight by 15 kg In the second year of monitoring occurred spontaneous pregnancy ended urgent delivery.

At objective inspection is established: the patient the right physique. Morphotype female. Uniform deposition of adipose tissue, creating a excess weight (body mass index — 36). Expressed hirsutism (hair growth on the upper lip, the chin, the breast and the white line of how can buy Super P Force online and the abdomen, extremities). Moderate hypertension (BP of 160/ 100 mm Hg. calendar). When vaginal study any noticeable deviations not identified 105. The uterus was determined naujalienes. The appendages were difficult to palpate due to the considerable thickness of subcutaneous fat of the anterior abdominal wall.

Clinical observations on stimulating effects of estrogen on the development of Super P Force 100mg + 60 mg online store and the uterus, with its infantilism, supported by the data of experimental studies that demonstrate the possibility of induction of fibroids prolonged administration of estrogens, served as a convincing proof of the role of estrogens in the development of benign hyperplasia of myo metry. According to our research, the 853 patients with uterine myoma with high frequency revealed morphological signs of hyperestrogenism: acyclic uterine bleeding (37,9%), late menopause (after 56 years) is 35.1%, hyperplasia hormoneproducing tissues of ovary — follicular cysts of the ovaries in the reproductive period (30,6%), hyperplasia of the stroma in the pre- (52.2%) and postmenopausal women (62,7%). Observed estrogenic colpocytologic type reactions in postmenopausal women (30.6 per cent) and obesity (54,2%) 87 as a marker of high estrogen background due to metabolic (aromatization) the conversion of Androstenedione to estrone in adipose tissue, which increases oestrogen pool in the body of the patient.

Antagonists are able to specifically bind with the receptors of Super P Force 100mg + 60 mg online store and GBV-WG, which are on the cell membranes of anterior pituitary (blocking them), and thus inhibit competitive binding of endogenous GN-WP receptors of the anterior pituitary. This blockade of receptors of the anterior pituitary causes a rapid decrease in the secretion of gonadotropins and decrease estrogenic background.

Historically, therapeutic approaches to the treatment of Super P Force 100mg + 60 mg for sale OTC and AGE have undergone a significant evolution, which can be divided into four stages. In the first stage, clinicians considered the possibility of observation of these patients is limited to symptomatic therapy. This stage can be described as the tactics of "non-interference". At some 160 extent this approach is justified by the observations of a long period of steady state of AGE without signs of disease progression. But most importantly, objectively led to this approach of "non-interference" — the lack of effective hormonal drugs which can inhibit proliferation of endometrial epithelium.

Progestins derived molecules norprogesterone, have a pronounced antiestrogenic antigonadotropnym properties and comparable derivatives of generic Super P Force in online store without prescription and nortestosterone, but at the same time do not carry androgenic potential.

Determined increased on both sides of best place to buy Super P Force 100mg + 60 mg online and the ovaries, their capsule thickened, smooth, white ("blue ovaries"). The cut visible multiple subcapsular follicular cysts with a diameter of 2-7 mm. Rare to find a yellow or white body. The cysts are usually lined with several layers of granulosa cells, but the most striking feature is hyperplasia of the theca internal surrounding a cystic follicles.

There have been many proposals for the classification of endometrial hyperplastic processes, especially until 1994. But in 1994, the who finally made the morphological classification, it meets the needs of how can buy Super P Force online and many researchers and clinicians, which helped to keep her up to date in an international instrument [38].

After the cessation of best place to buy Super P Force 100mg + 60 mg online and uterine bleeding (allocations) necessary to form the correct rhythm of best place to buy Super P Force 100mg + 60 mg online and the menstrual cycle. This should aim to restore to normal for this patient, the duration of the intermenstrual interval and decrease the duration and magnitude of blood loss during menstruation. The latter is achieved by attaching to estrogen therapy, progestin, or assignment of combined (estrogen-progestinami) contraceptive drugs. The use of estrogen in combination with progestin in an intermittent (cyclic) mode does not contradict the General principle of treatment, which consists in creating the anti-estrogenic effect on the endometrium. This provision is justified by the fact that the applied dose of estrogen in the discontinuous mode do not cause a significant proliferation of endometrial elements and their influence balanced by progestin. It should be borne in mind a number of positive properties of estrogen, such as the ability to increase the sensitivity of the endometrium to progestins, 153 to suppress the secretion of gonadotropins and reduce the intensity of steroidogenesis in the ovaries. With the help of estrogen fails to restore the correct rhythm of the menstrual cycle, which is not always achieved with the isolated use of progestins.

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