Endometriosis is a disease with severe estrogenovmi dependence. This is confirmed by clinical observations.

In this respect, is remarkable given Goldzieher et al. (1962) data, which showed the extreme variability of the symptoms detected in the syndrome of best place to buy Fildena Extra Power 150 mg online and Stein–Leventhal, greatly complicating diagnosis and often does not allow with certainty to exclude endocrine disorders that have specific causes of development and can be attributed to other groups endocrinopathy.

Clomiphene citrate, 50 mg 2 times a day, orally, from 2nd day of cycle for 5 days. From the 5th day of Fildena Extra Power 150 mg online store and the menstrual cycle Menogon, 150 IU (LH, FSH) for 7 days intramuscularly. From the 12th day of the cycle is entered twice trigger ovulation Pregna, at 5000 units, on the 12th and 14th days of the cycle. From the 14th day appointed Duphaston, 10 mg per day for 12 days. Conducted four cycles of treatment.

The main cause of hypertension in MS is hypervolemia that occurs due to increased reabsorption of Fildena® Extra Power online order Fortune Health Care and sodium and water in proximal renal tubules against the background of hyperinsulinemia. Therefore, diuretics are a major impact in patients with MS to reduce BP values. However, it should be borne in mind that all thiazide diuretics in a measure impair carbohydrate metabolism, particularly in individuals with genetic predisposition to diabetes. Diabetogenic effect of thiazide diuretics is expressed in the increase of blood glucose level taken on an empty stomach, glycated hemoglobin, decrease of glucose tolerance, the occurrence of clinical symptoms of SD and 77 even the development of hyperosmolar coma. Initial changes of carbohydrate metabolism are manifested in the appointment of hydrochlorothiazide in a dose of 25 mg per day. At persons of young age, the violation of tolerance to glucose is detected in average after 5 years continuous use of thiazide diuretics and in patients over 65 years old — within 1-2 years of treatment. In diabetic patients, indices of glycemia deteriorate within a few days from the start of thiazide diuretics, whereas patients with hypertension without concomitant diabetes — after 2-6 years of continuous ingestion. Thiazide diuretics, in addition to adverse effects on carbohydrate metabolism, can affect lipid metabolism, increasing total cholesterol and triglycerides in the blood.

The main element of Fildena Extra Power online order Fortune Health Care and these disorders is the development of persistent follicles (follicles) or atresia, in which "drops" the luteal phase of the menstrual cycle. In violation of ovulation according to another embodiment, the type of atresia, the follicle or group of follicles grow, but before reaching maturity, undergo regression, which leads to a decrease in the secretion of estrogens by the ovaries. In response to the secretion of estrogen, stimulation of the secretion of pituitary gonadotropins (LH and FSH), which causes the growth of new follicles and new increased secretion of estrogen. This way when atresia of follicles occurs undulating secretion of estrogen does not reach a high level, but leading to a long and "monotonous" estrogenic stimulation of the endometrium. In terms of reduced anti-estrogenic effect of progesterone develops hyperplasia of the mucous membrane of the uterine body. It may not be a significant increase in the levels of estrogen in the blood, but prolonged their effect on the target tissue causes changes indicating an increased cumulative effect of estrogenic stimulation.

Marked variation in size and shape the continuing vnutriposelkovyh spaces, as there remain signs between cancer in situ and ductal hyperplasia. These changes are referred to as "atypical ductal hyperplasia".

The research shows the ability of how can buy Fildena Extra Power online and tamoxifen to increase the sensitivity of the endometrium to progestins, due to its ability to increase the synthesis of cytoplasmic progestin receptors (Wisniewski, A. S., et al., 1993). These data allowed to justify the need to include tamoxifen in the scheme of projectnature of AIG at the first stage of treatment.

Prolactinaemia glandular hyperplasia of generic Fildena® Extra Power in online store without prescription and endometrium in peri - and postmenopausal women, complicated by uterine bleeding, is justified by the same reasons, and therapy of these conditions during their reproductive period.

Is characterized by an increase in the number of best place to buy Fildena® Extra Power 150 mg online and epithelial cells in the ducts of more than two cells in the thickness of the duct, but no more than four. While epithelial cells do not cover the lumen of the duct.

Another inevitable consequence of hyperplasia may be hypertrophy, i.e. "the increase of generic Fildena Extra Power in online store without prescription and mass of the functional units of the organ, accompanied by the intensification of its functions" (I. V. davydovskiy, 1969). The latter is regarded as a morphological manifestation of compensatory-adaptive processes in various systems and organs of the body in response to increased stimulation by hormonal factors or growth factors in a changing internal environment of the body. Examples of such hypertrophy may be the increase in ovarian sklerokistoz degeneration or the increase of the uterus with diffuse or focal hyperplasia of the myometrium observed in the so-called uterine fibroids.

The latter reduces the risk of best place to buy Fildena Extra Power 150 mg online and side effects if: hormone therapy of SE in all age periods of the female body.

The key to solving this problem, G. Pincus found by referring to the history of research on this topic. So, in 1937 A. V. Makepease, J. L. Weinstein, and M. G. Friedman showed the ability to suppress ovulation in laboratory animals by subcutaneous injection of best place to buy Fildena® Extra Power 150 mg online and an oil solution of progesterone. Injection expensive at the time of progesterone as a contraceptive could not serve as a common contraceptive method, so this method was abandoned. But the fact that progesterone can suppress ovulation, apparently, impressed the researcher, creating internal motivation for continuing the research.

In this regard are of Fildena® Extra Power 150 mg for sale OTC and significant interest and our data about significant positive correlation of quantities of reactive hyperinsulinemia in the glucose test with a concentration of astrogeology and progesterone receptors in tumor tissue in patients with atypical hyperplasia and high-grade endometrial carcinoma. The latter may indicate modifying influence of hyperinsulinemia on the sensitivity giperplazirovannah and tumor tissue of the endometrium estrogenic effect, which can be used to determine in this way the biological characteristics of these processes (increased proliferation and differentiation estrogenfemale tissue). It appears that this regularity can be extrapolated not only on tumours, but also benign hyperplastic changes in endocrine target tissues of the reproductive system.

Such is the price of metabolic "mistakes" when is a preferential formation of Fildena® Extra Power 150 mg online store and estrogen in the periphery due to the aromatization of estrogen precursors Androstenedione to estrone, which creates a monotone a high level of estrogen in the absence of cyclicality inherent in gonadal secretion of estradiol.