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Engorgement was observed in 33(26,4%) treated with HRT according to the classical scheme, and only 3 patients (5.7 percent) receiving Klimadinon (p=0.05).

The specific effect of the hormone is caused by interaction of buy Fildena® Super Active Fortune Health Care Ltd without prescription and the complex hormone–receptor with the corresponding nucleotide of DNA. The mechanism of interaction of the complex hormone–receptor as estradiol and progesterone are similar. However, to 45 of this interaction in the cell nucleus, there are important events that shed light on the details of this complex process.

Oddly enough, but in numerous publications on hormonal contraception, not even briefly sets out information relating to the authors of Fildena® Super Active 100 mg price online and the discovery of the phenomenon of hormonal inhibition of ovulation and the history of drugs.

Promegestone is one of the progestins, has attracted a large number of Fildena Super Active 100 mg price online and researchers and is known under the code number R-5020. This connection is not associated with a significant number of steroid receptors such as estrogen receptors, androgens, mineralocorticoids and glucocorticoids. Promegestone has a pronounced anti-estrogenic effect of the samples in vitro and in vivo. Connection reduces the effects of estrogen on the uterus and inhibits the proliferation of breast cancer cells in vitro. Promegestone quite strongly suppresses the secretion of luteinizing hormone (LH) on models in vivo and causes anovulation in women with normal menstrual cycle when taking high doses of the drug.

In 1981, D. Philibert et al. (1981) reported that they synthesized the compound, which had the property of antagonist in relation to progesterone receptors. This antiprogestin was marked by the authors as RU 38486. Later, this number was reduced to RU 486, and now the connection is called Mifepristone. Mifepristone has the properties of buy Fildena® Super Active 100 mg online and an antagonist not only to progesterone receptors, but the receptors of glucocorticoids. It is noteworthy that the ability Mifepristone to contact the progesterone receptor (affinity) is greater than five times (!) that progesterone and three times (!) the affinity of dexamethasone in relation to glucocorticoid receptors.

It turns out that even by circumstantial evidence, it is possible to recognize the absence of significant stimulation of buy Fildena Super Active 100 mg online and the mucous membrane of the uterine cavity and glandular tissue of the breast phytoestrogens, derived from the extract of black cohosh.

Earlier, when the studies of buy Fildena Super Active over the counter and the mechanism of signal transmission in the cell has been used the hormone with a radioactive label, believed that, e.g., estradiol or progesterone was associated with protein receptors in the cytoplasm, forming a complex hormone–receptor, entering the cell nucleus, where this complex started the process of RNA transcription.

As a result of these modifications dienoguest acquired positive properties in terms of absorption, distribution in the body and metabolism that are close to the characteristics of Fildena® Super Active 100 mg online price and derivative norprogesterone. This drug, with a very pronounced progestinum effect on the endometrium, other effects on the target tissue (estrogenic, anti-estrogenic and androgenic) was absent. Against this background, antigonadotropnym activity dienogest (suppression of secretion of FSH and LH) was determined not pronounced. So, antigonadotropnym activity dienogest (the ability to suppress the secretion of FSH and LH) in studies in women with preserved menstrual cycle was determined as weak. However, appointment to these patients dienogest (Visanne) orally, at a dose of 1 mg per day in the first phase of the cycle, significantly violated the mechanism of ovulation by eliminating predovlatorna increase secretion of estradiol associated with lack of ovulatory release of LH and FSH (violation of a positive feedback mechanism).

Treatment of obesity and insulin resistance an Important condition for the successful treatment of Fildena Super Active 100 mg price online and hypertension and obesity — understanding that the aim should not be to immediately reduce the body weight under the "ideal indicators". Quite at the beginning of treatment to reduce the rate of IC 5-10% of the original. Rapidly weight loss can be a significant stress for the metabolism, and faces certain complications.

Of course, the scope of this Chapter allows us to consider in detail all of Fildena Super Active 100 mg online price and the molecular bases of apoptosis, but some "key" factors, it is impossible not to mention. For example, the ovarian follicles secrete a protein factor "гонадокри52 NIN", which inhibits the development of other follicles (i.e. gonadorelin here already plays the role of physiological "control" population of cells ready to enter the stage of maturation).

If you experience uterine bleeding on the background of prolonged amenorrhea more than 1 year, after examination, recommended the appointment of buy Fildena® Super Active over the counter and "pure" progestins (provera, a Monitor, 166 Livial), in constant receive mode, for 3-4 months. Extremely effective introduction of the IUD "Mirena".

However, it is important to note that successful pharmacological correction of Fildena® Super Active 100 mg online price and the disease caused by hyperplastic process is possible only with simultaneous blocking of all signal cascades mediating pathological cell proliferation.

Another important reason for the increased estrogenic effect on the endometrium are changes in the metabolism of Fildena Super Active 100 mg price online and steroid hormones in adipose tissue, namely its ability, due to its the enzyme aromatase, to convert the precursors of estrogens (Androstenedione) to estrone. I must say that women with significant adipose tissue mass and duration of menopause more than 5 years this process of "peripheral" formation of estrogens, in essence, is only because of the endocrine function of the ovaries by this time is terminated.

A significant number of Fildena® Super Active 100 mg online price and recent studies (which constantly grows) is devoted to the quantitative determination of hormone receptors for estradiol and progesterone in the tumor tissue in the myometrium, allows to clarify the mechanism of the effect of estradiol and progesterone at the cellular level.

Benign changes in the breast, which in the overwhelming number of order Fildena® Super Active Fortune Health Care Ltd 100 mg online and cases is cell hyperplasia, form a rather heterogeneous group of disorders.

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