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Progestin — derivatives of 17-α-hydroxyprogesterone acetate retains its activity when taken orally and has a pronounced antiandrogenic property ОСОСН3 N ABOUT Medroxyprogesterone acetate COCH3 ОССН3 of buy Super Avana over the counter and Chlormadinone acetate C = O Cl CH3 CH3 ОСОСН3 ABOUT ОСОСН3 COCH3 COCH3 O CH3 Cl Cyproterone acetate Megestrol acetate CH2 127 5.1.4. Derivatives Norprogesterone In the last 15 years on the basis of a molecule 19-norprogesterone (missing the C-19 in the 10-position of the progesterone molecule) was synthesized several derivatives of 19-norprogesterone: promegestone, trimegestone, dimevision, nomegestrol acetate and-parties. The last four compounds are derivatives of promegestone.

Of course, the problem of functional organ-saving methods of order Super Avana Sunrise Remedies Pvt. Ltd. 60mg + 100 mg online and treatment in gynecology is currently attracting the attention of researchers and doctors. The possibilities of this approach will expand as hormonal compounds with high selective activity, can affect all levels of the reproductive and energy homeostatis. Ultimately, only such an approach will provide the clinical effectiveness of functional treatment methods.

In the next stage, obtained quite a large group of drugs which are derivatives of Super Avana 60mg + 100 mg online price and testosterone, the molecule of which has been replaced in the tenth position of the methyl group CH3 to atom of hydrogen (nortestosterone), and in 17-position was joined by various radicals. This was obtained by norprogesterone (or synthetic progestins) which had pronounced by progesterone effect on the endometrium, coupled with the ability in adequate doses, to inhibit the secretion of gonadotropins (FSH and LH). This dual effect of norprogesterone (Central and peripheral) undoubtedly stimulated the development of methods of hormonal contraception.

Clinical observations on stimulating effects of estrogen on the development of order Super Avana Sunrise Remedies Pvt. Ltd. 60mg + 100 mg online and the uterus, with its infantilism, supported by the data of experimental studies that demonstrate the possibility of induction of fibroids prolonged administration of estrogens, served as a convincing proof of the role of estrogens in the development of benign hyperplasia of myo metry. According to our research, the 853 patients with uterine myoma with high frequency revealed morphological signs of hyperestrogenism: acyclic uterine bleeding (37,9%), late menopause (after 56 years) is 35.1%, hyperplasia hormoneproducing tissues of ovary — follicular cysts of the ovaries in the reproductive period (30,6%), hyperplasia of the stroma in the pre- (52.2%) and postmenopausal women (62,7%). Observed estrogenic colpocytologic type reactions in postmenopausal women (30.6 per cent) and obesity (54,2%) 87 as a marker of high estrogen background due to metabolic (aromatization) the conversion of Androstenedione to estrone in adipose tissue, which increases oestrogen pool in the body of the patient.

Normalization of the menstrual cycle combined with the "glandular regression" endometrial hyperplasia equally often in patients receiving the three-phase drug Trisiston (91,6%) and two-phase Anteovin (91,0%). It was noted the lower frequency of buy Super Avana over the counter and clinical and morphological effects in patients who were prescribed progestin without estrogenic component (azetomepregenol, a monitor) in 59% of cases (p<0,05). Weaker clinical and morphological effect of "pure" progestins, in our opinion, can be attributed to the lack of estrogen — etinilestradiola, which can substantially increase the sensitivity of the endometrium to the effects of progestins.

These properties of phytoestrogens allows them to be characterized as selective modulators of estrogen. This term indicated the ability of Super Avana 60mg + 100 mg online price and phytoestrogens to change (mo polirovat) the transcription process of the hormonal signal in the target tissue depending on its α - or β-subtypes of the receptors of estradiol. Both subspecies of the receptors of estradiol contained in tanahmerah, have the same affinity (the affinity) to estradiol. But an increased affinity for β-receptors have phytoestrogens. The latter are located primarily in the bones, ovaries and urogenital tract. While α-estradiol receptors predominate in the anterior pituitary, mammary gland and endometrium. Given this distribution of the subspecies estradiolo receptors in target tissues it is clear that phytoestrogens can simultaneously create estrogenic effect at the level of the hypothalamus and not have such at the level of the endometrium.

In practice, the poor reproducibility of diagnosis of Super Avana 60mg + 100 mg price online and endometrial hyperplasia and atypical endometrial hyperplasia in the analysis of the results of multicenter studies have led to the need to reduce the number of cases attributable to hyperplastic changes of the endometrium. That is why a new approach to understanding the pathogenesis of the disease to identify it includes genetic, clinical and histomorphological results of follow-up in relation to risk of malignancy hyperplastic changes.

Third-generation progestins progestins are derived levonorgestrel — desogestrel, gestodene and norgestimate. These compounds are rapidly absorbed after ingestion.

Already from the name of order Super Avana Sunrise Remedies Pvt. Ltd. 60mg + 100 mg online and the syndrome shows that its basis is the phenomenon of hyperplasia, i.e. an increase in the number of structural elements tissues by their excess, but controlled education. On a cellular level the basis of hyperplastic syndrome is excessive physiological proliferation (increase in cell number and intracellular structures), which in norm provides the conditions for cyclic renewal of tissues and cells in the organs of the female reproductive system for reproduction of the species. The phenomenon of cell proliferation (lat.

Taking into account this classification, the highest risk of buy Super Avana over the counter and developing breast cancer observed in groups of women whose breast cancer was detected signs of atypical proliferation.

The elucidation of the mechanism of order Super Avana Sunrise Remedies Pvt. Ltd. 60mg + 100 mg online and signal transmission of extracellular factors through the cell membrane allowed to make one important conclusion. If hydrophilic hormones can affect both the activity of enzymes (proteins) and their synthesis, the hydrophobic hormones can influence only on protein synthesis, implemented through the transcription of the corresponding genes.

The basis for the development of buy Super Avana Sunrise Remedies Pvt. Ltd. without prescription and hirsutism in women (regardless of the source of androgens) are usually two mechanisms: 1) increase the level of androgens in the blood and (or) 2) increased activity of 5a-reductase converts locally in the hair follicle testosterone to dihydrotestosterone (DHT), which is implemented actually androgenic effect.

It should be borne in mind that the stromal hyperplasia stromal differs from hipertensa lack of buy Super Avana 60mg + 100 mg online and luteinizing stromal cells.

As a result of these modifications dienoguest acquired positive properties in terms of absorption, distribution in the body and metabolism that are close to the characteristics of buy Super Avana Sunrise Remedies Pvt. Ltd. without prescription and derivative norprogesterone. This drug, with a very pronounced progestinum effect on the endometrium, other effects on the target tissue (estrogenic, anti-estrogenic and androgenic) was absent. Against this background, antigonadotropnym activity dienogest (suppression of secretion of FSH and LH) was determined not pronounced. So, antigonadotropnym activity dienogest (the ability to suppress the secretion of FSH and LH) in studies in women with preserved menstrual cycle was determined as weak. However, appointment to these patients dienogest (Visanne) orally, at a dose of 1 mg per day in the first phase of the cycle, significantly violated the mechanism of ovulation by eliminating predovlatorna increase secretion of estradiol associated with lack of ovulatory release of LH and FSH (violation of a positive feedback mechanism).

After the end of buy Super Avana over the counter and lactation is marked atrophy of glandular tissue and stroma again becomes the dominant component of the breast.

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