It should be noted that the above-mentioned test for evaluating the activity of the progestin-only method, specific binding of Tadacip® 20 mg for sale OTC and steroid to protein receptor, because informative enough and time savings, now largely replacing the previously used biological test Trip (test progestin-only activity in immature rabbit according to the severity of the secretory transformation of the endometrium).

Experimental justification of Tadacip® 20 mg online store and this conclusion was based on the data of comparative study of the influence of estradiol and black cohosh extract on the weight of the uterus in ovariectomized rats. Thus, the administration of estrogen for 3 months led to a significant increase in weight of the uterus, while the introduction of black cohosh extract and this effect was not accompanied.

As can be seen from the data presented, a panel of generic Tadacip in online store without prescription and qualified pathologists based on the results obtained in the morphological study of biopsy material of mammary glands, came to the conclusion about the fitness of epithelial hyperplasia at risk of malignant transformation of the epithelium of the mammary glands.

In the next stage, obtained quite a large group of drugs which are derivatives of generic Tadacip in online store without prescription and testosterone, the molecule of which has been replaced in the tenth position of the methyl group CH3 to atom of hydrogen (nortestosterone), and in 17-position was joined by various radicals. This was obtained by norprogesterone (or synthetic progestins) which had pronounced by progesterone effect on the endometrium, coupled with the ability in adequate doses, to inhibit the secretion of gonadotropins (FSH and LH). This dual effect of norprogesterone (Central and peripheral) undoubtedly stimulated the development of methods of hormonal contraception.

Progestins, which will go below it, according to its chemical structure belongs to the class of best place to buy Tadacip® 20 mg online and steroids, the structural basis of which is cyclopentanoperhydrophenanthrene skeleton. Terenowy skeleton consists of four interlinked rings. At each corner of the skeleton (structural formula) are atoms of carbon. The number of these atoms in the molecule of the steroid and the structure of the side chain are highlighted: 1) the pregnane (C-21), this group consists of progesterone and adrenocortical hormones

On the material the authors have shown that of best place to buy Tadacip 20 mg online and AGE in the reproductive age often occurs against a background of glandular hyperplasia (79,5%), postmenopausal — atrophy (68,4%). The operated patients in a significant number of observations was determined hyperplasia of the ovarian stroma (70,0%) and follicular cysts (45,0%). These data can be considered as a morphological marker of estrogens and indirect indicator of its role in the Genesis of the disease.

Later, immunohistochemical methods using monoclonal antibodies to the complexes of estradiol receptor and progesterone receptor, were able to show that the binding of generic Tadacip in online store without prescription and steroid hormone and its receptor occurs exclusively in the cell nucleus. Nevertheless, the study of the content of the receptors of estradiol and progesterone in cellular cytosol, adopted in laboratory practice currently reflects the number of receptors that are separated from the nucleus and cytoplasm during processing of the tissue studied.

As is known, the reduction of Tadacip 20 mg online store and dopaminergic influence of the hypothalamus on the anterior pituitary is a common cause of decreased fertility in women, accounting for 35-40% of cases among all types of endocrine infertility. Hypothalamic dysfunction in the form of reduced dopaminergic influence mediobasal nuclei of the hypothalamus to the anterior pituitary, and the consequent violation of the rhythm of secretion of gonadotropins (FSH and LH) and increased prolactin secretion leads to breakage of the mechanism of ovulation, the rhythm of the menstrual cycle or amenorrhea and infertility.

A significant number of Tadacip® online order Cipla Limited and recent studies (which constantly grows) is devoted to the quantitative determination of hormone receptors for estradiol and progesterone in the tumor tissue in the myometrium, allows to clarify the mechanism of the effect of estradiol and progesterone at the cellular level.

Appealed with complaints of excessive body weight, hirsute symptoms, menstrual disorders, which have become more pronounced in the last three years and acquired features of best place to buy Tadacip 20 mg online and oligomenoree. Secondary infertility. All breaches began to develop after five years from the onset of menarche (over 14 years). The patient married 8 years. In the first year of marriage got pregnant, but the pregnancy was interrupted by spontaneous abortion at term of 6 weeks. In the intervening period, pregnancy does not occur. Were examined, but random. Husband patients were examined (semen), found healthy.

It is well known that the role of insulin in metabolism goes far beyond just regulating the level of Tadacip® 20 mg online store and glucose in the blood. In adipose tissue insulin stimulates the formation of fat and inhibits lipolysis. In muscle, insulin activates glycogen synthesis and promotes the transition of amino acids into cells, which stimulates the synthesis of proteins and prevents their collapse, and activates the synthesis of ATP, DNA and RNA and in this way stimulates the cell proliferation. Increases intracellular concentration of sodium and potassium ions.

The generally accepted judgment about the causes of generic Tadacip® in online store without prescription and obesity is the idea of excessive consumption of food containing fat, due to low physical activity. If the mass of consumed fat exceeds the organism's capacity for its utilization, is the development and progression of obesity. Saturated fatty acids in excess of dietary, cause structural changes of phospholipids of cell membranes and the disruption of the expression of genes controlling the conduction of the signal of insulin into the cell. Fats more calories than proteins and carbohydrates (1 gram of fat contains 9 calories, whereas protein and carbohydrates at 4 kcal), so when consuming fat the body gets two times more calories than when consuming proteins and carbohydrates, with the same amount of food.

19-Norprogesterone not active when taken orally. However, the modification of Tadacip 20 mg for sale OTC and its chemical structure by introducing a double bond in position C6-7, methyl group at C-6 and acetyl radical in position C-17 has led to the receipt of nomegestrol acetate, a highly active progestin, active ingestion.

Hyperplasia of the endometrium causes a persistent and prolonged elevated levels of Tadacip online order Cipla Limited and estradiol in the blood or in normal level, the absence of cyclical fluctuations and sufficient blood level of progesterone, which are two important components of the menstrual cycle. If we turn to the pathophysiological reasons for the phenomenon of increased estrogenic effect on the endometrium, it should be point out the most common violations: 1) persistence or atresia of follicles in the ovaries