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It is interesting to note that thirty years later, this position is expressed by M. F. Glazunov, has not been refuted, and, moreover, finds supporters among oncomorphology in our days. So, neyshtadt E. L. and O. A. Vorobiev in his monograph on "Pathology of Vigora 100 mg online price and breast cancer" (2003) write: "increasingly, the view that proliferative processes in the breast, and carcinoma of this organ do not have direct communication, and cancer occurs in morphologically unaltered tissue. At the same time it must be emphasized that the point of view according to which the epithelial proliferative directly transferred to cancer, are declarative in nature and has not been supported by experimental and clinical confirmation" (p.158).

At the cellular level, the sequence of events leading to the development of Vigora 100 mg price online and high intracellular concentration of estradiol, which plays a key role in the development of the disease. At the heart of this process lies on the polymorphism of genes (variation in DNA), providing a high activity of different cytochromes and transferases. In the first phase endometrial cells is an active local production of the enzyme aromatase (cytochrome CYP19), which stimulates the conversion of C-19 steroids to estrogens.

Estrogen-stimulated cell proliferation, determined in target tissues of the female reproductive system is largely implemented through the insulin-like growth factors 1 and 2 (IGF-1 and IGF-2). The levels of Vigora 100 mg online price and these proteins and their receptors under the influence of estrogen stimulus increases rapidly, and the resulting cascade of signals transmitted to them on estrogen-dependent genes, with subsequent stimulation of cell proliferation.

The pathogenetic relationship between reproductive function and energy homeostasis of the organism clearly seen on the "household level". Well known by all athletes the dependence of Vigora® 100 mg price online and the correct rhythm of the menstrual cycle on body weight: at its lowering below the critical level (44-46 kg) comes amenorrhea. Permanent cessation менстру58 sexual cycle due to hypothalamic changes designed to maintain the constancy of the internal environment of the organism in conditions of increased energotrast. Another example is amenorrhea wartime due to starvation and reduced intake of energy resources from outside.

Of course, the problem of functional organ-saving methods of buy Vigora® German Remedies Private Ltd. without prescription and treatment in gynecology is currently attracting the attention of researchers and doctors. The possibilities of this approach will expand as hormonal compounds with high selective activity, can affect all levels of the reproductive and energy homeostatis. Ultimately, only such an approach will provide the clinical effectiveness of functional treatment methods.

Estrogen is the main hormonal factor that causes proliferation of the endometrium. In terms of order Vigora® German Remedies Private Ltd. 100 mg online and reduced influence of progesterone, which is often due to anovulation, estrogen can cause the expressed proliferation of glandular and stromal elements of the endometrium which rapidly acquires the morphological characteristics of hyperplastic changes.

To this end: – patient with 5-day menstrualnopodobnoe reaction, which may occur 8-10 days after the last progestin введе162 tion, transferred to a cyclic treatment of combined (estrogen-progestinami) contraceptive drugs prescribed for contraceptive scheme for 4-6 cycles. Preference is given to preparations of Vigora® 100 mg price online and the second generation with a large progestin-only activity (Microgynon, Rigevidon) in patients older than 46 years (46-55 years) of steroid contraceptive drugs are prescribed continuously (1 tab. a day) for 3-4 months, which leads to the preservation of persistent amenorrhea.

Therefore, in the future, use non-toxic selective antiproliferative and antineoplastic agents, specifically blocks the activity of buy Vigora over the counter and factor NFkB, resulting in the simultaneous inhibition of pathological cell proliferation, neoangiogenesis, invasion, and inhibition of chemotherapy of hormoneresistant can be a very effective strategy in the prevention and treatment of hyperplastic processes and malignant diseases of various organs and tissues.

Long-term (5-year) results of treatment of Vigora 100 mg online price and patients with of AGE traced in the work of the Y. Bohman, L. V. Arsenova and A. A. Nikonov (1992) performed in the gynecologic Oncology Department, Institute of Oncology, Ministry of health of the RSFSR, which covers many important aspects of the treatment and evaluation of the effectiveness of hormone therapy of AGE. The experience of the authors based on the observation of 220 patients of AGE. Of this number, 104 have determined the structural atypia (mean age 43.9 years), and 116 — with cell AGE (average age of 47.2 years). As the authors note, for "structural atypia characterized by close focal or diffuse location of the glands, with narrow layers of stroma between them. In histological sections expressed the tortuosity of the glands and their tree-like branching appears bizarre form of their combinations, budding of the epithelium, formation of papillae and about cribrosa structures."

Growth factors are presented, the essence of polypeptides, stimulating (or inhibiting) the division and development of buy Vigora 100 mg online and certain cells, such as fibroblasts of the stroma of the endometrium. The growth factors include epidermal growth factor (EGF), insulin growth factor-1(IGF1) (somatomedin) and insulin growth factor-2 (IGF-2), growth factor neurons (NGF), and fibroblast growth factor (FGF), transforming growth factor (Tgfß) and several others.

Already relatively long ago it is known (data from studies conducted in the early 1970-ies) that the patients with syndrome of inadequate SKA is determined by the increased concentration of order Vigora German Remedies Private Ltd. 100 mg online and LH in the blood at comparatively constant and low level of FSH. Until recently it was unclear the nature of gonadotropin secretion with primary disturbances in the hypothalamic-pituitary system or changes in the secretion of LH and FSH due to the failure of the feedback mechanism in the result of abnormal steroidogenesis in polycystic ovaries, adrenal glands or both glands together.

I must say that both enzyme PI3K and Akt, is known today as a key signaling proteins that mediate the proliferative cellular processes, have received this status not so long ago, in the middle of Vigora® 100 mg price online and 1990-ies.

I believe that the ability to inhibit the transcriptional activity characteristic of buy Vigora over the counter and the domains of the two isoforms of the RPR, but it manifests itself mainly in RP-A. the Latter can be explained by the difference in the spatial arrangement of the protein molecules in the cell. In this situation, the molecule PR-BUT is connected to a cofactor different from the cofactor molecules of RP-V (cofactor — nonprotein substance whose presence is necessary for the implementation of the specific effect of the protein), and such пу46 the isomer And acquires the ability to inhibit the transcriptional activity of isomer-B.

Stroma consists of buy Vigora German Remedies Private Ltd. without prescription and different quantities of adipose and fibrous connective tissue, forming the volume of the breast outside periods of lactation.

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