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Third-generation progestins progestins are derived levonorgestrel — desogestrel, gestodene and norgestimate. These compounds are rapidly absorbed after ingestion.

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Further, convincing data about local hyperestrogenism in the system of the uterine arteries that supply the myometrium and the tumor (Savitsky G. A. and others, 1980) and increased content of buy Filitra 60 mg online and cytosolic receptors for estradiol detected in the tissue of the fibroids.

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Promegestone connection, the most studied for their biological effects, and known in the literature under the code name R-5020. The drug has a high affinity for progesterone receptors but does not bind with the receptors of estrogens, androgens and glucocorticoids. Promegestone has a pronounced anti-estrogen effect, proved both in vitro and in vivo. Reduces the binding of order Levitra Fortune Healthcare Pvt. Ltd. 20 mg online and estrogen to the uterus and inhibits proliferation of breast cancer cells in models in vitro. Promegestone suppresses the secretion of LH in the hypothalamic-pituitary level in the experiment in vivo. At high doses to women with normal menstrual cycles were developed as amenorrhea.

The main cause of hypertension in MS is hypervolemia that occurs due to increased reabsorption of order Filitra Fortune Healthcare Pvt. Ltd. 20 mg online and sodium and water in proximal renal tubules against the background of hyperinsulinemia. Therefore, diuretics are a major impact in patients with MS to reduce BP values. However, it should be borne in mind that all thiazide diuretics in a measure impair carbohydrate metabolism, particularly in individuals with genetic predisposition to diabetes. Diabetogenic effect of thiazide diuretics is expressed in the increase of blood glucose level taken on an empty stomach, glycated hemoglobin, decrease of glucose tolerance, the occurrence of clinical symptoms of SD and 77 even the development of hyperosmolar coma. Initial changes of carbohydrate metabolism are manifested in the appointment of hydrochlorothiazide in a dose of 25 mg per day. At persons of young age, the violation of tolerance to glucose is detected in average after 5 years continuous use of thiazide diuretics and in patients over 65 years old — within 1-2 years of treatment. In diabetic patients, indices of glycemia deteriorate within a few days from the start of thiazide diuretics, whereas patients with hypertension without concomitant diabetes — after 2-6 years of continuous ingestion. Thiazide diuretics, in addition to adverse effects on carbohydrate metabolism, can affect lipid metabolism, increasing total cholesterol and triglycerides in the blood.

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