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Another important characteristic of GS in the reproductive system is expressed by the ability of its morphological substrate to respond to corrective antiproliferative hormonal effects, causing the suppression of buy Fildena Strong 120 mg online and cell proliferation, and the resulting regression of the morphological changes. A natural consequence of this impact is the restoration of normal menstrual cycle or stop it. Plenty of examples of this — regression of glandular hyperplasia of the endometrium as a result of prolonged hormone therapy progestinami, or more clear evidence of this effect was reversible growth suppression of uterine fibroids or regression after the introduction of analogues of gonadotropin-releasing hormone or antiprogestogen (Mifepristone), which provides the possibility of making savings of surgical interventions.

Orlistat (xenical) inhibits the absorption of fats of buy Fildena® Strong 120 mg online and food in the gastrointestinal tract by inhibiting gastrointestinal lipase, a key enzyme carrying out the hydrolysis of triglycerides food, the release of fatty acids and monoglycerides. As a result, about 30% of triglycerides from food are not absorbed, which creates a deficit of calories compared to using only reduced-calorie diet. Orlistat used for those patients who prefer fatty foods, because with excessive consumption of carbohydrates the drug ineffective.

In this monograph explains the possibility of buy Fildena Strong 120 mg online and combining the diversity of functional disorders in the female reproductive system, due to uncompensated giperestrogenia and it induced hyperplastic processes in one concept — "hyperplastic syndrome" (TOS). Under the "syndrome" here means the totality of symptoms with common pathogenesis.

At objective examination, and inspection is established: the patient the right physique, without being overweight (a body mass index — 24) and hirsutism. Morphotype — female. Secondary sexual attributes are well expressed. When vaginal study determined neuveritelne, easily movable, heavy uterus. In the projection of buy Fildena Strong Fortune Health Care without prescription and uterine appendages on both sides are defined slightly enlarged dense ovaries. In tests of functional diagnostics revealed a consistent anovulation and elevated levels of estrogen background on протяже104 research Institute of only the menstrual cycle. The levels of FSH, LH and prolactin measured in the mid-follicular and luteal phases of the menstrual cycle corresponded to normal values. Ultrasound of the pelvic organs is noted: the uterus is reduced in size (45×30×42 mm) with smooth contours, the endometrium is thin — 7 mm (18-th day of the menstrual cycle), the ovaries are enlarged in linear size: right — 5.4 cm and the left 5.6 cm. In the tissue of enlarged ovaries was determined by multiple small follicular cysts up to 7 mm in diameter. Determined thickened tunica sheath of the ovaries, with reduced echogenicity.

Second ciasnym cascade, friendly first (IDA) are the two enzyme — phosphoinositol-3-kinase and its direct molecular target — serine-treoninove kinase-Akt (PI3K/Akt-kinany cascade). In normal cells MAR and PI3K/ Akt signaling cascades, is considered a classic ways of order Fildena® Strong Fortune Health Care 120 mg online and conducting signals from growth factors, important to regulate many physiological processes related not only with the mitogenic cellular activity, but also regulation of cell metabolism. In particular, the PI3K/Akt cascade is involved in the regulation of glucose metabolism, posreduj holding signal of insulin. However, it is authentically established that hyperactivation of these two basic signaling pathways in many types of hyperplastic processes and malignant tumors.

The main cause of hypertension in MS is hypervolemia that occurs due to increased reabsorption of buy Fildena Strong over the counter and sodium and water in proximal renal tubules against the background of hyperinsulinemia. Therefore, diuretics are a major impact in patients with MS to reduce BP values. However, it should be borne in mind that all thiazide diuretics in a measure impair carbohydrate metabolism, particularly in individuals with genetic predisposition to diabetes. Diabetogenic effect of thiazide diuretics is expressed in the increase of blood glucose level taken on an empty stomach, glycated hemoglobin, decrease of glucose tolerance, the occurrence of clinical symptoms of SD and 77 even the development of hyperosmolar coma. Initial changes of carbohydrate metabolism are manifested in the appointment of hydrochlorothiazide in a dose of 25 mg per day. At persons of young age, the violation of tolerance to glucose is detected in average after 5 years continuous use of thiazide diuretics and in patients over 65 years old — within 1-2 years of treatment. In diabetic patients, indices of glycemia deteriorate within a few days from the start of thiazide diuretics, whereas patients with hypertension without concomitant diabetes — after 2-6 years of continuous ingestion. Thiazide diuretics, in addition to adverse effects on carbohydrate metabolism, can affect lipid metabolism, increasing total cholesterol and triglycerides in the blood.

To the woman in the example, to gradually reduce body weight, the daily caloric content of buy Fildena Strong 120 mg online and its diet should not exceed 2005 kcal. It should be borne in mind that the main supplier of calories — fats, and plant fats are not lower in calories than animal, though less "harmful". The proportion of fat should account for no more than 30% of total calories in the daily diet, this amount of animal fats — up to 10% vegetable to 20%. The share of carbohydrates in the daily diet should be 50% and protein 20%.

What is the way out of the situation and where to find it? "Highlight and describe on the basis of Fildena® Strong 120 mg price online and available clinical and laboratory data of the pathogenetic variants of the disease! This approach to solving complicated problems always helped many researchers, writing a dissertation!" — advised us of the ingenious reader. Well, after some hesitation, but follow this advice. This approach has its own truth.

Clomiphene citrate is assigned to 50 mg 2 times a day from 2nd day of buy Fildena Strong Fortune Health Care without prescription and cycle, inside 5 days. The monitoring of the growth of primordial follicle under the influence of the treatment (ultrasound). Upon reaching the dominant follicle size 18-20 mm is introduced, the trigger of ovulation is a hormone with LH activity of human Chorionic gonadotropin in a dose of 5000-10 000 IU/day at the 14th and 16th days of the cycle.

From the foregoing it becomes clear that not only G. Pincus created the hormonal contraception, although he was a "generator" of the main idea. The efforts of Fildena® Strong 120 mg price online and talented chemists, fellow experimenters and doctors involved in the study, people who all worked on the result. But Mr. Pincus still had the "nerve" of the idea of hormonal contraception, and many difficult trials of her "strength", his authority of a biologist and an expert on the physiology of the reproductive system have saved the situation in terms of the organization of laboratory research and obtaining adequate financial assistance.

Already in 1934, at age 31, G. Pincus in the laboratory performed the IVF procedure, by fertilization of the egg of Fildena Strong 120 mg online price and the rabbit in vitro with subsequent embryo transfer into the uterus. These experiments characterize G. Pincus as a biologist pioneer, already at that time started to develop methods of assisted reproductive technology in the experiment.

Another important characteristic of GS in the reproductive system is expressed by the ability of its morphological substrate to respond to corrective antiproliferative hormonal effects, causing the suppression of buy Fildena® Strong Fortune Health Care without prescription and cell proliferation, and the resulting regression of the morphological changes. A natural consequence of this impact is the restoration of normal menstrual cycle or stop it. Plenty of examples of this — regression of glandular hyperplasia of the endometrium as a result of prolonged hormone therapy progestinami, or more clear evidence of this effect was reversible growth suppression of uterine fibroids or regression after the introduction of analogues of gonadotropin-releasing hormone or antiprogestogen (Mifepristone), which provides the possibility of making savings of surgical interventions.

Obesity, moderate hypertension and increased excretion of order Fildena Strong Fortune Health Care 120 mg online and DEA is not allowed to completely eliminate adrenal Genesis of the syndrome or a combination of adrenal hyperandrogenism and syndrome PKA. For the differential diagnosis conducted dexamethasone suppression test (2 mg/day for 3 days). On the third day of the test, the level of DHEAS decreased to 14.0 nmol/l (50%) and the testosterone level decreased slightly to 3.8 nmol/L. based on these data it was impossible to completely eliminate the mixed type of hyperandrogenism (ovarian and adrenal origin) that may occur with the syndrome PKA.

The effect of buy Fildena Strong Fortune Health Care without prescription and clomiphene on shifts in the reproductive system of buy Fildena Strong 120 mg online and the patient it is "pathogenic". The drug inhibits the hypothalamus and anterior pituitary estradiol receptors, which causes elimination of the effect of estrogen on these structures. As a result of such actions is the increased secretion of GBV-WG and the release of adenogipofiza FSH and LH reaches its peak of secretion at the time of cancellation clomiphene. An increase in the level of FSH in the blood stimulates the maturation of follicles in the ovaries and increased synthesis of estradiol in granulosa cells. The increase in the level of estradiol in blood by the middle of the menstrual cycle initiates the positive feedback mechanism ovulatory LH surge. There is a rupture of the follicle and ovulation, with subsequent changes in the female reproductive system, characteristic of a normal ovulatory cycle recovery of ovulation, normalization of menstrual cycle rhythm, restoration of fertility, and the elimination of hyperplastic processes in the target organs.

In a simplified form to facilitate understanding of the complex structure of order Fildena Strong Fortune Health Care 120 mg online and signaling pathways in the cell, one can imagine that in the cytoplasm there are three key signaling cascade by the process of phosphorylation kanatami: first MAR minasny cascade (mitogen activated protein kinases)

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