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The resistance of buy Kamagra Polo® over the counter and the patient to the treatment clomiphene citrate can be predicted if the patient is over 30 years

Numerous endocrine studies in recent years, including a highly specific radioimmunoassay and ELISA methods for the determination of buy Kamagra Polo 100 mg online and hormones in the blood, used in patients with glandular hyperplasia of the endometrium, allow to unambiguously recognize the etiological role of estrogens in the development of excessive proliferative changes in the mucosa of the uterine cavity.

And last but not less important. We are talking about the protein p53, which is regarded as a universal factor inhibiting cell proliferation, and under certain conditions, and neoplastic transformation. In many, if not all, types of apoptosis in cells increase the content and activity of protein p53. The fact that the protein p53 activates genes of buy Kamagra Polo Ajanta Pharma Limited without prescription and a number of "killer" receptors, i.e. receptors that perceive the "command" of the beginning of apoptosis. Among them, proteins of the Fas-receptor and the receptor KILLER/DR5. In this way increases the sensitivity of cells to signals that trigger apoptosis. Another important function of p53 protein is its ability to stop cell cycle. This is due to the activation of the P21 gene, whose product (P21 protein) inhibits the well-known complexes of cyclins (cyclin-Cdks).

Cause inadequate secretion of buy Kamagra Polo Ajanta Pharma Limited without prescription and gonadotropins with high LH/FSH ratio is the initial increase in the content of estrogen with the change in the functioning of the system of feedback between estrogens and the hypothalamo-pituitary complex.

On the background of buy Kamagra Polo® 100 mg online and above noted facts, it is no exaggeration to say that basal and reactive hyperinsulinemia, 63 detected in patients with hyperplasia and adenocarcinoma of the endometrium, can be considered as a factor that modifies the sensitivity of the mucous membrane of the uterus to hormonal effects through stimulation of the synthesis of endometrial receptors for steroid hormones. Positive and significant correlation between the amount of reactive hyperinsulinemia and content of receptors to estradiol and progesterone in endometrial tumor tissue that is established in our study can provide some evidence of such interaction.

The complexity of the problem is extremely varied clinical manifestation of order Kamagra Polo® Ajanta Pharma Limited 100 mg online and disorders in the female reproductive homeostat syndrome SCA, combined with impaired secretion of peptide and steroid hormones, which play a key role in shaping the various phenotypes of the disease. Hence the difficulty in identifying a clear clinical criteria of the syndrome, and attempt to highlight several pathogenetic variants of the disease, in order to optimize treatment methods. It remains unclear what starts the chain of pathological events (hypothalamic disorder or development sclerocystic changes in the ovaries?) and how important is the role of genetic mechanism in the development of the syndrome.

Indirect methods are aimed at estimating the effect of buy Kamagra Polo Ajanta Pharma Limited without prescription and endogenous insulin, secreted under the influence of oral glucose load. These include the oral glucose tolerance test (PGTT) and intravenous glucose tolerance test (WGTT).

The principal methods of buy Kamagra Polo® over the counter and basic therapy of FAM, which is usually combined with vitamin therapy, the administration of such drugs and tranquilizers, according to testimony. Recently there is a widespread herbal that contains estrogenic substance in the treatment of FEMME breast. There are already reliable clinical observation on the effectiveness of their use in the treatment of this disease. Thus, the clinical efficacy of mastodynon in the treatment of diffuse forms of adenose was 79.4%, which was almost equal to the effect of combined oral contraceptives (88-90%) and progestins (76%) (Davydov M. I., Letyagin V. P., 2006).

The development of order Kamagra Polo Ajanta Pharma Limited 100 mg online and hypertension is associated pathogenetically with MS and serves as its marker. Central nervous system and the kidneys retain insulin sensitivity that in conditions of hyperinsulinemia is a factor of activation of the sympathetic nervous system and increase vascular tone.

Progestins derived molecules norprogesterone, have a pronounced antiestrogenic antigonadotropnym properties and comparable derivatives of buy Kamagra Polo Ajanta Pharma Limited without prescription and nortestosterone, but at the same time do not carry androgenic potential.

The results of buy Kamagra Polo Ajanta Pharma Limited without prescription and these tests showed that the syndrome SCA hyperandrogenism may have a double origin: determined by increased secretion of androgens by the adrenal glands and ovaries.

Long-term (5-year) results of treatment of buy Kamagra Polo Ajanta Pharma Limited without prescription and patients with of AGE traced in the work of the Y. Bohman, L. V. Arsenova and A. A. Nikonov (1992) performed in the gynecologic Oncology Department, Institute of Oncology, Ministry of health of the RSFSR, which covers many important aspects of the treatment and evaluation of the effectiveness of hormone therapy of AGE. The experience of the authors based on the observation of 220 patients of AGE. Of this number, 104 have determined the structural atypia (mean age 43.9 years), and 116 — with cell AGE (average age of 47.2 years). As the authors note, for "structural atypia characterized by close focal or diffuse location of the glands, with narrow layers of stroma between them. In histological sections expressed the tortuosity of the glands and their tree-like branching appears bizarre form of their combinations, budding of the epithelium, formation of papillae and about cribrosa structures."

In relation to the female reproductive system it should be noted that hyperplasia and subsequent hypertrophy of buy Kamagra Polo 100 mg online and hormone-dependent tissues morphologically most pronounced in the reproductive age. Processes can purchase diffuse (fibroadenomatosis of the mammary glands) or a base (uterine fibroids) view, but actually in the vast majority of cases these changes are not true tumors, but the result of activation of cell growth factors and proliferation in response to estrogen stimulation uncoordinated.

19-Norprogesterone not active when taken orally. However, the modification of buy Kamagra Polo over the counter and its chemical structure by introducing a double bond in position C6-7, methyl group at C-6 and acetyl radical in position C-17 has led to the receipt of nomegestrol acetate, a highly active progestin, active ingestion.

In target tissues of Kamagra Polo® 100 mg price online and the female reproductive system in normal and pathological conditions, initially, there are several levels (cascades) that transmit the signal from ligand outside the cell nucleus. Transmitted in this way, the signal leads to the activation of transcription of target genes, stimulating cell growth and proliferation.

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