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In the next stage, obtained quite a large group of drugs which are derivatives of buy Brand Cialis over the counter and testosterone, the molecule of which has been replaced in the tenth position of the methyl group CH3 to atom of hydrogen (nortestosterone), and in 17-position was joined by various radicals. This was obtained by norprogesterone (or synthetic progestins) which had pronounced by progesterone effect on the endometrium, coupled with the ability in adequate doses, to inhibit the secretion of gonadotropins (FSH and LH). This dual effect of norprogesterone (Central and peripheral) undoubtedly stimulated the development of methods of hormonal contraception.

In simple hyperplasia of endometrium glands have a tubular (tubular) type, though there are cystic or angular forms glands. Pseudostratified in the lining of buy Brand Cialis 20 mg online and glands formed by cells with an elongated nucleus without atypia. The whole picture of this type of glandular hyperplasia of the endometrium presented a balanced reaction of glands and stroma.

Methods of treating metabolic syndrome 3.3.1. General principles Treatment patients with MS is planned taking into account the possibilities of Brand Cialis 20 mg online price and achieving compensation for major violations that constitute the pathogenetic basis of this syndrome. Therefore, the main therapeutic effects are carried out to reduce body weight, achieve good metabolic control and stabilization of normal blood pressure and prevention of acute or remote cardiovascular complications.

For a proper menstrual cycle after you stop uterine bleeding or any day of buy Cialis® Eli Lilly and Company without prescription and the amenorrhea apply: estrogen-progesterone contraceptives monophasic type, contraceptive (cyclic) scheme. The first cycles after stopping the bleeding can be unstable, which may require increasing the daily dose to 2-3 tablets a day, in case of bleeding. In these patients it is advisable to use drugs monophasic type (Microgynon, Ovidon) to take into account and easily change the daily dose in the first cycle of treatment, depending on the haemostatic effect (cessation of bleeding). After a break in receiving the drug (3-5 days) and the onset of a new menstrual cycle, the treatment is carried out at the contraceptive scheme, lasting at least 6-8 cycles.

The limited volume of Brand Cialis 20 mg online price and this Chapter does not allow to elaborate on all the methods and drugs used for the treatment of MS in patients of all ages. Yes this is not a special need, as a gynecologist for the treatment of hyperplastic syndrome, coupled with metabolic disorders, will be forced to consult with collagenation, who will prescribe an adequate treatment, putting the regimens and doses of the drugs.

The key to solving this problem, G. Pincus found by referring to the history of research on this topic. So, in 1937 A. V. Makepease, J. L. Weinstein, and M. G. Friedman showed the ability to suppress ovulation in laboratory animals by subcutaneous injection of order Brand Cialis Eli Lilly and Company 20 mg online and an oil solution of progesterone. Injection expensive at the time of progesterone as a contraceptive could not serve as a common contraceptive method, so this method was abandoned. But the fact that progesterone can suppress ovulation, apparently, impressed the researcher, creating internal motivation for continuing the research.

For better tolerance of Brand Cialis 20 mg online price and hormonal medications, taken by mouth, additionally appointed cholagogue, vitamin E (200-300 mg daily), Pancreatin or complex of enzymes (Festal).

These properties of phytoestrogens allows them to be characterized as selective modulators of estrogen. This term indicated the ability of Brand Cialis 20 mg online price and phytoestrogens to change (mo polirovat) the transcription process of the hormonal signal in the target tissue depending on its α - or β-subtypes of the receptors of estradiol. Both subspecies of the receptors of estradiol contained in tanahmerah, have the same affinity (the affinity) to estradiol. But an increased affinity for β-receptors have phytoestrogens. The latter are located primarily in the bones, ovaries and urogenital tract. While α-estradiol receptors predominate in the anterior pituitary, mammary gland and endometrium. Given this distribution of the subspecies estradiolo receptors in target tissues it is clear that phytoestrogens can simultaneously create estrogenic effect at the level of the hypothalamus and not have such at the level of the endometrium.

Syndrome Stein–Leventhal? after a short pause, clearly gathering his thoughts, complements the response of the student head of the gynecological Department, a specialist with 40 years of Brand Cialis 20 mg price online and experience. Is a complex multi-endocrine syndrome, probably inherited, manifested disorders of the rhythm of secretion of gonadotropins, development sclerocystic changes in the ovaries that causes them to increase, and disorders of ovulation, the oligomenorrhea, disruption of steroidogenesis in the ovaries, with a predominance of synthesis of androgens, and hirsutism and, ultimately, to infertility. The disease is often associated with metabolic abnormalities in the form of hyperinsulinemia, insulin resistance, and obesity. Therapeutic approaches are varied and include drug therapy and surgery (wedge resection of the ovaries), aimed at restoring ovulation. Of curing disease in the conventional sense of the term is not observed, it is usually a question of compensation the most obvious violations of hormonal levels (hyperandrogenism) and restore reproductive function.

And last but not less important. We are talking about the protein p53, which is regarded as a universal factor inhibiting cell proliferation, and under certain conditions, and neoplastic transformation. In many, if not all, types of apoptosis in cells increase the content and activity of protein p53. The fact that the protein p53 activates genes of buy Brand Cialis over the counter and a number of "killer" receptors, i.e. receptors that perceive the "command" of the beginning of apoptosis. Among them, proteins of the Fas-receptor and the receptor KILLER/DR5. In this way increases the sensitivity of cells to signals that trigger apoptosis. Another important function of p53 protein is its ability to stop cell cycle. This is due to the activation of the P21 gene, whose product (P21 protein) inhibits the well-known complexes of cyclins (cyclin-Cdks).

Young women interested in pregnancy during the second stage of order Brand Cialis Eli Lilly and Company 20 mg online and treatment is shown the use of stimulants ovulation (clomiphene citrate, counterparts GBV-WG). Pregnancy on the background of treatment with her natural progestational effect on the endometrium prevents the possibility of recurrence of AGE. the abolition of progestins.

In comparison with the antiandrogen (AA) non-steroidal structure (Flutamide, Nilutamide, Bikalutamid) the above steroid AA, as well as non-steroidal, competitive bind to receptors of Brand Cialis 20 mg price online and testosterone and DHT, but in addition are able to maintain their progesterone properties, in particular to suppress the secretion of buy Cialis® 20 mg online and gonadotropins and lower levels of testosterone in the blood. Such dual effect steroid AA definitely has benefits in the treatment of patients with hyperplastic syndrome, combined with manifestations of increased influence of testosterone on the skin and its appendages. With this purpose, widely used cyproterone acetate is included as progestinums (!) component in combined oral contraceptives in patients with manifestations of hyperandrogenism (Femoden, Chloe, Diane-35, etc.). 5.3. Antiprogestin After the opening of the transmission mechanism of the influence of progestins on the target tissue via the progesterone receptor (1970), the researchers pretty convincingly suggested that should sushestvo AMB steroid compounds that can selectively (selectively) block the binding of hormone to the receptor and thus to determine antiprogesterone effect. A decade later, such a connection was allocated.

Histological examination of scrapings of Cialis® 20 mg online price and the mucous membrane of the uterus diagnosis of glandular hyperplasia of the endometrium is usually straightforward. Determined glands of various shapes and sizes. Along with the smaller glands are large, Katowice advanced. They lined vysokovitaminnym epithelium with multiple row arrangement of nuclei and clearly defined edges apikalnym cells.

Of the 33 patients, the normalization of buy Cialis® Eli Lilly and Company without prescription and the rhythm of the menstrual cycle at the end of the treatment Mastodynia occurred in 25 (75.8 per cent).

The pathogenetic relationship between reproductive function and energy homeostasis of the organism clearly seen on the "household level". Well known by all athletes the dependence of buy Brand Cialis 20 mg online and the correct rhythm of the menstrual cycle on body weight: at its lowering below the critical level (44-46 kg) comes amenorrhea. Permanent cessation менстру58 sexual cycle due to hypothalamic changes designed to maintain the constancy of the internal environment of the organism in conditions of increased energotrast. Another example is amenorrhea wartime due to starvation and reduced intake of energy resources from outside.

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