Activated signaling proteins transcription factors and chief among them — NF-kB directly or indirectly (through the activation of other transcription factors) stimulate the expression of SildiSoft online order Sunrise Remedies and genes controlling proliferation, differentiation, apoptosis, adhesion and cell motility. Among them are genes encoding proteins-regulators of cell cycle cyclins and cyclin-dependent kinases, receptors, growth factors, insulin-like growth factor (IGF) and many other proteins.

Pathognomonic symptom of how can buy Viagra Soft online and anatomical polyps is a thin base (stem), the presence of which differentiates polyps from polypoides forms glandular hyperplasia of the endometrium.

In theoretical terms, for example SKA well traced the possible influence of disorders of generic Viagra Soft in online store without prescription and secretion of peptide hormones of the anterior pituitary and steroid in the ovaries for the formation of the morphological picture of the disease, its "substrate", which is not always possible to trace other endocrinopathy. The complexity of the pathogenesis of the syndrome PKA is determined by the complex of metabolic disorders that are often associated with the disease.

The peculiarity of these compounds is quite pronounced estrogen influence on the hypothalamic-pituitary complex and weak in peripheral tissues target. Moreover, under certain conditions (preferential binding to β-estrogen receptors in target tissues) perhaps even a manifestation of Fildena CT online order Centurion Laboratories and the anti-estrogenic effect of phytoestrogens, which creates a "safe" conditions for their application in patients with indicate a history of hormone-dependent tumors. Such selectivity effects of phytoestrogens in relation to receptors in target tissues, creating a multidirectional effects, allows us to characterize them as compounds with selective activity (Klimadinon, Bionorica-Germany).

As a result of best place to buy Viagra Soft 100 mg online and these shifts occurs unrestrained hypersecretion of GBV-WG, and as a result, — increased secretion of LH with normal or even reduced level of secretion of FSH.

In other words, for the development of generic Viagra Soft in online store without prescription and severe proliferation of the endometrium along with the high content of estrogen in the blood plays an important role, and normal or even reduced levels of estrogen if their performance remain monotonous for quite a long time (the time factor). This conclusion is of great importance for the explanation of the role of estrogens are relatively low when there is no significant increase in the level of estrogen in the blood and however, against this background, determined by endometrial hyperplasia.

Assigned therapy clomiphene citrate 100 mg daily from the fifth day of how can buy Sildenafil Soft Tablets online and the cycle for 5 days. On the third cycle of treatment, the patient became pregnant, which was uneventful and ended urgent delivery.

But we will not seek premature generalizations, but rather, let's try "point" analysis of the sequence of best place to buy Viagra Soft 100 mg online and development of all pathophysiological events in the reproductive system in this disease. So, hirsutism and infertility associate with the syndrome PKA and rightly seen as manifestations of Fildena CT 50 mg for sale OTC and hyperandrogenism. This raises a fair question: what is the source of increased production of androgens in patients with PCA — the adrenal glands or the ovaries? 91 or they together create an elevated androgen levels in the body, causing hirsutism and infertility? In a healthy ovary, as in the adrenal gland, secreted three main androgen: Androstenedione, testosterone and dehydroepiandrosterone (DHEA). The main ovarian androgens are Androstenedione and testosterone, secreted by stromal cells and internal theca of the follicle. DHEA and its sulfate (DHEA-S) are the major androgens secreted by the net area of the adrenal cortex. In addition to the adrenal glands and ovaries third component androgennogo pool in the female body are metabolic transformations (extraglandular) of the precursor androgens Androstenedione, and testosterone in tissues such as skin, fat, muscle, and brain. The contribution of metabolic schooling of androgens in androgeny pool of the organism is 50%, whereas the adrenal glands and ovaries contribute 25%! In other words, the value of androgen levels in the body healthy women formed only due to the metabolic conversion of precursor androgens into Androstenedione and testosterone in the periphery, is equal to the sum of the values of androgens secreted by the adrenal glands and ovaries combined! This multi-level in the formation of hormones gives rise, on the one hand, the diagnostic difficulties in determining the primary source of hyperandrogenism, and on the other in patients with SCA requires the inclusion in the therapeutic scheme of drugs that reduce the effect of androgens at the tissue level (the target tissue) and in this way mitigating symptoms hirsutula syndrome.

Important education in the tertiary structure of a protein molecule, determining the possibility of how can buy Viagra Soft online and its transcriptional abilities is domain. Domains are regions in the tertiary structure of the protein with a degree of autonomy. Domains can, independently from the other parts of the protein molecule to support and even shape the spatial structure of the protein chain.

In simple hyperplasia of endometrium glands have a tubular (tubular) type, though there are cystic or angular forms glands. Pseudostratified in the lining of Viagra Soft 50 mg online store and glands formed by cells with an elongated nucleus without atypia. The whole picture of this type of glandular hyperplasia of the endometrium presented a balanced reaction of glands and stroma.

On violation of this inhibiting the secretion of Viagra Soft 100 mg online store and GBV-WG system at SCA syndrome show some clinical observations. So determined in patients an increased level of secretion of LH detects a high sensitivity to the inhibitory effect of exogenous dopamine. The introduction of the antagonist of opiate receptors naloxone or synthetic -endorphin — not changed increased secretion of LH in patients with syndrome SCA. In healthy women with normal cycles of the same dose of antagonist of opiate receptors naloxone, and agonist — -endorphin, respectively cause an increase or decrease secretion of LH.

Adequate treatment for atypical endometrial hyperplasia in any age period is the therapy with progestins. Treatment progestins are aimed at preventing the transition of atypical hyperplasia to invasive cancer, increasing structural and cell differentiation, secretory transformation and desquamation of Sildenafil Soft Tablets 50 mg online store and the endometrium, with subsequent development of atrophic changes in the mucous membrane of the uterine cavity.

Pronounced degree of how can buy Viagra Soft online and atypical endometrial hyperplasia, especially in the study of scrapings, often difficult and sometimes almost impossible to distinguish from highly differentiated forms of cancer of the endometrium.

Defining drug treatment of Viagra Soft 100 mg for sale OTC and obesity, it is necessary to remember about high degree of cardiovascular risk in patients MS and take into account the influence of drugs.