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Given the above, it can be assumed that morphological changes in the ovaries and disorders of steroidogenesis in these glands in patients with syndrome SCA can be the consequence not the primary genetic or enzymatic defects, and inadequate gonadotropin stimulation. With the increase in ratio of buy Triple Trial Pack without prescription and LH/FSH, as is the case with SKA, chronic stimulation of tissue theca LH may cause excessive formation and secretion of androgens. At the same time granulosa cells, devoid aromatase activity because of the shortage of FSH, lose the ability to form the necessary amount of estrogen.

Nuclear factor NF-kB is a complex of proteins having transcription activity. The term "transcription" means the formation in the cell nucleus at the appropriate gene (localized in one chromosome), the special mediator messenger RNA (mRNA). mRNA carries out the second stage of gene expression, designated as "stream", ie protein synthesis at the ribosomes of Triple Trial Pack 20 mg + 20 mg + 100 mg online price and the cell according to the program dictated by the mRNA. Ribosomes in the broadcast play the role of "molecular machines" for the proper interaction of all participants of process. Nuclear transcription factor found in all mammalian cells and plays an important role in the maturation, differentiation and adaptation of cells to new physiological conditions. Its increased activity is logged in aging, chronic inflammatory, autoimmune and oncological diseases.

The normal increase in cell pool and, therefore, the tissue mass is the essence of order Triple Trial Pack 20 mg + 20 mg + 100 mg online and hyperplastic changes that meet the physiological needs of the body and providing the proper functioning of the reproductive homeostat. The main feature of this process is controlled by cell proliferation (lat. proles — offspring, ferre — to carry, to create) and intracellular structures (mitochondria, etc.), which ensures the growth and differentiation of tissues in the process of individual development and the implementation of reproductive function. Under normal conditions, the process of cell proliferation provides a continuous cyclic update of the pool of cell and tissues. In cases of violation of hormonal homeostasis, causing a pronounced non-cyclic hormonal stimulation of the tissue target and cell proliferation, determined by the increase in the number of structural elements of the endocrine tissues by their excess, but controlled education, which is the hyperplasia.

Determined increased on both sides of Triple Trial Pack 20 mg + 20 mg + 100 mg price online and the ovaries, their capsule thickened, smooth, white ("blue ovaries"). The cut visible multiple subcapsular follicular cysts with a diameter of 2-7 mm. Rare to find a yellow or white body. The cysts are usually lined with several layers of granulosa cells, but the most striking feature is hyperplasia of the theca internal surrounding a cystic follicles.

The basic idea in the methods of treatment of GP is normally consisted of buy Triple Trial Pack 20 mg + 20 mg + 100 mg online and in an effort to create strong anti-estrogenic effect at the level of tissues-targets in order to suppress the proliferative effect of estrogen. To this purpose, the patient is usually prescribed a fairly high dose of androgens in the form of intramuscular injections of testosterone-propionate or methyltestosterone purpose inside. Such anti-oestrogenic effects provide a positive clinical result in the cessation of bleeding and partial regression of GP while achieving significant total dose of injected androgens. However, anti-estrogenic effect is achieved quite often accompanied by side reactions because of high doses of androgens used in the form of swelling, excessive greasiness of the skin and hirsute manifestations, which was seen as a "necessary evil" of the ongoing hormone therapy.

Second, selective increased secretion of Triple Trial Pack 20 mg + 20 mg + 100 mg online price and Androstenedione during adrenarche can be explained by the change in the correlation of activity of corresponding enzymes (e.g., increase in the activity of 17,20-of desmolase and decreased activity of 3-hydroxysteroid dehydrogenase) in the mesh area, which leads to increased biosynthesis of androgens.

Chapter 4 TYPES of Triple Trial Pack 20 mg + 20 mg + 100 mg price online and DISORDERS IN the FEMALE REPRODUCTIVE SYSTEM, DUE to HYPERPLASTIC CHANGES IN TARGET TISSUES 4.1. Glandular hyperplasia of endometrium Recurrent glandular hyperplasia of the endometrium may cause abnormal uterine bleeding in all periods of the reproductive cycle of the female body. Juvenile uterine bleeding in adolescence, bleeding in menopause, and perimenopausal and postmenopausal women in a large number of observations (up to 60-75%) is due to hyperplastic changes in the mucous membrane of the uterine cavity.

With these considerations in mind, it is important to emphasize that, for example, to compensate for the lack of yellow body, any progestin, but for fully adequate therapy should choose the drug which, in addition to the main effect, to alleviate the symptoms accompanying hormonal imbalance (hyperandrogenism, mastodinia, etc.).

Here Decapeptide bind to receptors of buy Triple Trial Pack over the counter and the anterior pituitary, stimulating the synthesis and release of FSH and LH into the bloodstream.

Appealed with complaints of excessive body weight, hirsute symptoms, menstrual disorders, which have become more pronounced in the last three years and acquired features of Triple Trial Pack 20 mg + 20 mg + 100 mg price online and oligomenoree. Secondary infertility. All breaches began to develop after five years from the onset of menarche (over 14 years). The patient married 8 years. In the first year of marriage got pregnant, but the pregnancy was interrupted by spontaneous abortion at term of 6 weeks. In the intervening period, pregnancy does not occur. Were examined, but random. Husband patients were examined (semen), found healthy.

It should be noted that, once begun, the process is almost independent of Triple Trial Pack 20 mg + 20 mg + 100 mg price online and the starting factors, and one stage passes into another. It all starts with the condensation of chromatin of the cell nucleus and its cytoplasm. As a result, the nucleus becomes fragmented, and the cytoplasm, decreasing in volume, changes the shape of the cell. The next stage apoptosis is the fragmentation of the nucleus and cytoplasm with the formation of apoptotic cells. The nucleus splits into fragments, surrounded by a nuclear membrane. These fragments contain very dense masses of chromatin. At the end of this process of apoptotic Taurus ethnoreligious. Some Taurus are nuclear fragments, in others only the cytoplasmic contents. But those and others are surrounded by plasmalemma with slightly modified composition. And then what happens is what happens already with the bodies that became foreign for the organism: the phagocytosis of apoptotic Taurus the surrounding cells (phagocytes, нейтро53 filmi, etc.). Phagocytosed them corpuscles are rapidly destroyed in phagolysosome.

Another consequence of age-related increase of buy Triple Trial Pack without prescription and hypothalamic threshold of sensitivity to the glucose signal to hypothalamic satiety center is increased appetite and excessive food intake, increase of glycemia and the resulting increased secretion of insulin. Hyperinsulinemia provides an increase of fat reserves and the development of metabolic obesity, increased synthesis of lipoproteins of low and very low density in the liver.

The positive morphological effect of buy Triple Trial Pack 20 mg + 20 mg + 100 mg online and hormone therapy KOK "pure" progestins in the form of a regression of glandular hyperplasia of the endometrium confirmed the data of ultrasound scanning of the mucous membrane of the uterine cavity. The last was expressed by a decrease in echogenicity and acoustic density of the M-echo and the reduction of the thickness of the endometrium 5 to 6 mm (20-22 day cycle). In patients who have not observed morphological effect, an ultrasound scan revealed increase in size of the uterine cavity, irregular acoustic density M-echo

By external examination giperplazirovannah endometrium in the material of the scraping looks like a thick and juicy layer of buy Triple Trial Pack 20 mg + 20 mg + 100 mg online and the mucous membrane of buy Triple Trial Pack over the counter and the uterine cavity, often with propovedniki areas. Scraping abundant, resembling in appearance fabric, which is obtained when performing curettage on 26-28 th day of the normal secretory cycle. Another picture is observed in the dilatation and curettage in postmenopausal women. The scraping of the mucous membrane is usually scarce, and the morphological study revealed only small foci of GE in a small number. According to the morphological characteristics of the GOE is characterized by the proliferation of as glands and stroma, which provides the appearance and giperplazirovannah mucosa in the form of a yellowish velvety mass of lobed form with polipoesia structures. Despite the presence of proliferation as glands and stroma, microscopy tissues were detected mainly clusters of glandular structures of GE. Glands have the form of a tubular coiled structures, which highly vary in shape and number. Sometimes the gland can be considerably enlarged, forming a cystic structure. 84 secretory activity in these glands usually absent, but if happens, then in the form of a small and rare tricks. Mitoses are present, but the number does not exceed the observed in the endometrium proliferative type. In General, cystic changes in the endometrium (changes resembling the picture of "Swiss cheese") are a symptom of its already low activity state, with no potential for proliferative changes.

A significant number of order Triple Trial Pack 20 mg + 20 mg + 100 mg online and recent studies (which constantly grows) is devoted to the quantitative determination of hormone receptors for estradiol and progesterone in the tumor tissue in the myometrium, allows to clarify the mechanism of the effect of estradiol and progesterone at the cellular level.

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